The SUBSTANCE burns so hot,
it melts flesh like tallow.
Game of Thrones Season 2, Episode 5
It's useful for calculating the number
of atoms in a SUBSTANCE,
The Big Bang Theory Season 9, Episode 10
Substance abuse is a lifelong struggle.
The Big Bang Theory Season 1, Episode 10
Do you think the coffee had
any other SUBSTANCE?
Money Heist Season 3, Episode 7
Manufacture of a Schedule II
Breaking Bad Season 2, Episode 4